Inducible Hepatic Porphyrias and Regulation of Heme Synthesis
Meyer UA, Marver HS. 1971. Chemically induced porphyria: increased microsomal heme turnover after treatment with allylisopropylacetamide. Science 171:64-6.
Meyer UA, Strand LJ, Doss M, Rees AC, Marver HS. 1972. Intermittent acute porphyria. Demonstration of a genetic defect in porphobilinogen metabolism. N Engl J Med 286:1277-82
Correia MA, Meyer UA. 1975. Apocytochrome P-450: reconstitution of functional cytochrome with hemin in vitro. Proc Natl Acad Sci USA 72:400-4
Lindberg RLP, Porcher C, Grandchamp B, Ledermann B, Bürki K, Brandner S, Aguzzi A and Meyer UA. 1996. Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Nature Genet 12:195-9
Lindberg RLP, Martini R, Baumgartner M, Erne B, Borg J, et al. 1999. Motor neoropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria. J Clin Invest 103:1127-34
Podvinec M, Handschin C, Looser R, Meyer UA. 2004. Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proc. Natl. Acad. Sci. USA 101:9127-32
Handschin C, Lin J, Rhee J, Peyer AK, Chin S, et al. 2005. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell 122:505-15
Common Genetic Polymorphisms of Drug Disposition
Meier UT, Meyer UA. 1987. Genetic polymorphism of human cytochrome P450 S-mephenytoin-4-hydroxylase. Biochemistry 26:8466-74
Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, et al. 1988. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331:442-46
Skoda RC, Gonzalez FJ, Demierre A, Meyer UA. 1988. Two mutant alleles of the human cytochrome P-450db1 gene (P4502D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci USA 85:5240-43
Zanger UM, Hauri HP, Loeper J, Homberg JC, Meyer UA. 1988. Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II. Proc Natl Acad Sci USA 85:8256-60
Heim M, and Meyer UA. 1990. Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification. Lancet 336:529-32
Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA. 1990. Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J Biol Chem 265:17209-14
Blum M, Demierre A, Grant DM, Heim M, Meyer UA. 1991. Molecular mechanism of slow acetylation in man. Proc Natl Acad Sci USA 88:5237-4
Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, and Meyer UA. 1991. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymprhism. Am J Hum Genet 48:943-50
Heim MH, Meyer UA. 1992. Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. Genomics 14:49-58
de Morais SMF, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, Goldstein JA. 1994. The major defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 269:15419-22
Transcriptional Regulation of Drug Disposition
Früh FW, Zanger UM, Meyer UA. 1997. Extent and character of phenobarbital-mediated changes in gene expression in liver. Mol Pharmacol 51:363-9
Handschin C, Podvinec M, Meyer UA. 2000. CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proc Natl Acad Sci USA 97:10769-74
Ourlin JC, Baader M, Fraser D, Halpert JR, Meyer UA. 2000. Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37). Arch Biochem Biophys 373:375-84
Handschin C, Podvinec M, Stöckli J, Hoffmann K, Meyer UA. 2001. Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds tu humans. Mol Endocrinol 15:1571-85
Handschin C, Podvinec M, Amherd R, Looser R, Ourlin JC, Meyer UA. 2002. Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. J Biol Chem 277:29561-7
Podvinec M, Kaufmann MR, Handschin C, Meyer UA. 2002. NUBIScan, an in-silico approach for prediction of nuclear receptor response elements. Mol Endocrin 16:1269-79
Oscarson M, Zanger UM, Rifki OF, Klein K, Eichelbaum M, Meyer UA. 2006. Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther 80:440-56
Rencurel F, Foretz M, Kaufmann MR, Stroka D, Looser R, et al. 2006. Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol 70:1925-34
Blattler SM, Rencurel F, Kaufmann MR, Meyer UA. 2007. In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase. Proc Natl Acad Sci USA 104:1045-50
Roth A, Looser R, Kaufmann M, Blattler SM, Rencurel F, et al. 2008. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Mol Pharmacol 73:1282-9
Major Reviews
Meyer UA, Zanger UM. 1997. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu Rev Pharmacol Toxicol 37:269-96
Meyer UA, Schuurmans MM, Lindberg RLP. 1998. Acute Porphyrias: pathogenesis of neurological manifestations. Sem Liver Dis 18:43-52
Meyer UA. 2000. Pharmacogenetics and adverse drug reactions. Lancet 356:1667-71
Handschin C, Meyer UA. 2003. Induction of Drug Metabolism: the role of nuclear receptors. Pharmacol Rev 55:649-73
Meyer UA. 2004. Pharmacogenetics - five decades of therapeutic lessons from genetic diversity. Nature Rev Genet 5:669-76
Meyer UA. 2007. Genes and the individual response to treatment. In LANCET-Treating Individuals, ed. P Rothwell. Oxford: Elsevier Ltd. pp 151-68
Meyer UA. 2007. Endo-xenobiotic crosstalk and the regulation of cytochromes P450. Drug Metab Rev 39:639-46
Meyer UA, Zanger UM, Schwab M. 2013. Omics and drug response. Annu Rev Pharmacol Toxicol 53:475-502
